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Seeking exceptionally talented bioinformaticians with a strong biostatistics background to join our team The position will focus on the processing, analysis and downstream application of data generated from Sengenics’ KREX technology-based products The successful candidate will work closely with our technical/scientific team to support the exploratory analysis and reporting processes
The ideal candidate(s) should be a motivated team player with strong understanding of omics data, as well as experience in computational biology for building effective algorithms and tools necessary to support our internal and external projects
Perform bioinformatics and/or statistical analysis on multivariable datasets in order to identify biomarkers relevant to disease/clinical manifestations
Develop pipelines for data wrangling and pre-processing, analysis and visualisation purposes
Able to perform data mining by retrieving public databases for pathway, network and disease associations and collate with proprietary data
Able to maintain Sengenics’s proprietary databases
Able to interpret and summarise the results into report, manuscripts and/or patents
Able to communicate and interact the bioinformatics results with the colleagues, stake holders and collaborators
Masters (MSc)/Doctorate (PhD) level individual with experience in computational biology, bioinformatics, statistics, and/or biological science or equivalent research/industrial experience
Strong experience in at least one of these scripting languages R, Python and/or Perl Knowledge with other object-oriented programming such as Python, C++ or Java is an added advantage
Experience with machine learning algorithms and prior knowledge of proteomics and molecular biology is ideal but is not necessary
Strong ability to work on multiple projects simultaneously and manage work with minimum supervision
Critical independent thinking, excellent prioritisation of tasks, good team player, problem solving attitude, as well as excellent communications and presentation skills are favourable
Deadline:30th Jan 2020
Sengenics is a Functional Proteomics company that was originally spun out from research carried out at Cambridge University in the UK.
The company has a patented technology called KREX™ which has world renowned customers and collaborators that include top pharma, biotech and ivy league institutions in the USA, Europe and Asia.
KREX™ is the world's only correctly folded, full-length protein array technology. The fundamental principle of KREX™ is that when the protein of interest is correctly folded, it co-translationally drives the correct folding of BCCP. Which then becomes biotinylated and allows the fusion protein to become attached to the surface. On the other hand, when the protein of interest is grossly misfolded, it co-translationally drives misfolding of BCCP so it can no longer become biotinylated, preventing it from attaching to the surface. These proteins simply get washed away.
The key application of KREX™ is the discovery of autoantibody biomarkers for:
Drug efficacy, irAEs and companion diagnostics
Infectious diseases and vaccines
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